Ceftiofur Hydrochloride (103980-44-5)
ọja Apejuwe
Ceftiofur jẹ oogun aporo aisan ti iru cephalosporin (iran kẹta), ti a fun ni iwe-aṣẹ fun lilo ninu oogun oogun.O ti kọkọ ṣe apejuwe rẹ ni ọdun 1987.
O jẹ sooro si awọn aporo resistance henensiamu beta-lactamase, o si ni iṣẹ ṣiṣe lodi si mejeeji Giramu-rere ati awọn kokoro arun Giramu odi.E. coli igara sooro si ceftiofur ti a ti royin.
Ceftiofur Hydrochloride jẹ fọọmu iyọ hydrochloride ti ceftiofur, semisynthetic kan, beta-lactamase-iduroṣinṣin, gbooro-spekitiriumu, cephalosporin iran-kẹta pẹlu iṣẹ ṣiṣe antibacterial.Ceftiofur sopọ mọ ati ṣe aiṣiṣẹ awọn ọlọjẹ-abuda penicillin (PBPs) ti o wa lori awọ inu ti ogiri sẹẹli kokoro-arun.Awọn PBPs jẹ awọn enzymu ti o ni ipa ninu awọn ipele ipari ti iṣakojọpọ ogiri sẹẹli kokoro-arun ati ni atunṣe odi sẹẹli lakoko idagbasoke ati pipin.Imuṣiṣẹpọ ti awọn PBP ṣe idiwọ pẹlu ọna asopọ agbelebu ti awọn ẹwọn peptidoglycan pataki fun agbara odi sẹẹli ati rigidity.Eyi ni abajade ni irẹwẹsi ti odi sẹẹli kokoro-arun ati ki o fa lysis sẹẹli.
| NKANKAN | AWỌN NIPA | Esi | |
| Ifarahan | Funfun to Pa-funfun Crystalline lulú | Ṣe ibamu | |
| Idanimọ | Awọn akoko idaduro ti awọn ipò tente ninu awọn chromatogram ti a gba pẹlu ojutu idanwo ni ibamu si ti tente oke akọkọ ninu chromatogram ti a gba pẹlu ojutu itọkasi. | Ṣe ibamu | |
| Idahun ti kiloraidi | Ṣe ibamu | ||
| Ifarahan ti ojutu | wípé | Ko lagbara ju No.1 Turbidity Standard | <1 |
| Àwọ̀ | Ko ṣokunkun ju ojutu boṣewa Y9 | <8 | |
| Solubility | Soluble ni N, N- Dimethylacetamide, die-die tiotuka ni 5% ti iṣuu soda bicarbonate ati kẹmika. | Ṣe ibamu | |
| PH | 2.0 ~ 3.0 | 2.2 | |
| Omi akoonu | 1.5% ~ 4.0% | 1.6% | |
| Specific opitika Yiyi | -115°~-127° | -117° | |
| Irin eru | NMT 0.0020% | Ṣe ibamu | |
| Aloku ti iginisonu | NMT 0.20% | 0.15% | |
| Awọn nkan ti o jọmọ | Aimọ ti o tobi julọ | NMT 0.20% | 0.09 |
| Lapapọ awọn idoti | NMT 1.50% | 0.38 | |
| Awọn nkan ti o ku | Ethyl acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0.006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0.0001 | |
| Ayẹwo | Ceftiofur Hydrochloride | NLT 98.0% | 100.4% |
| Kloride | 6.0% ~ 6.5% | 6.2% | |
| Endotoxin kokoro arun | Kere ju 0.20EU/mg | Ṣe ibamu | |
| Ailesabiyamo | Ṣe ibamu pẹlu idanwo naa | Ṣe ibamu | |
| Iwọn patiku | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| IKADI | Awọn abajade idanwo naa ni ibamu si NI pato | ||
