Gliclazide (21187-98-4)
ọja Akojọ
Gliclazide jẹ oogun antidiabetic ti ẹnu sulfonylurea.O jẹ kristali funfun tabi lulú kristali, ti ko ni oorun ati adun.
Gliclazide jẹ iran 2nd ti oral sulfonylurea hypoglycemic oluranlowo pẹlu igbese to lagbara.Ilana rẹ jẹ iru si ti toluenosulfonylurea, ie, yiyan ṣiṣẹ lori awọn sẹẹli β-pancreatic lati ṣe igbelaruge yomijade hisulini ati mu itusilẹ hisulini pọ si lẹhin jijẹ glukosi, eyiti ko le mu iṣelọpọ ti awọn alaisan alakan nikan, ṣugbọn tun mu ilọsiwaju tabi ṣe idaduro iṣẹlẹ ti awọn ilolu iṣọn-ẹjẹ dayabetik.
Gliclazide jẹ lilo akọkọ fun ìwọnba ati iwọntunwọnsi iru II mellitus àtọgbẹ pẹlu ibẹrẹ agbalagba nibiti ounjẹ ati iṣakoso adaṣe nikan ko munadoko ati laisi ifarahan si ketosis, ati pe o tun ṣe ilọsiwaju awọn ọgbẹ fundus ati ijẹ-ara ati awọn ailagbara iṣan ni awọn alaisan alakan.
Ohun elo
A lo Gliclazide fun iṣakoso hyperglycemia ni gliclazide-idahun àtọgbẹ mellitus ti iduroṣinṣin, ìwọnba, ti kii-ketosis prone, iru àtọgbẹ 2.Ti a lo nigbati àtọgbẹ ko le ṣakoso nipasẹ iṣakoso ounjẹ to dara ati adaṣe tabi nigba itọju insulini ko yẹ.
| Idanwo | Awọn pato | Awọn esi ti onínọmbà |
| Ifarahan | Funfun tabi fere funfun lulú. | Iyẹfun funfun |
| Solubility | Ni iṣe ti ko ṣee ṣe ninu omi;larọwọto tiotuka ni methylene kiloraidi;tiotuka diẹ ninu acetone;tiotuka die-die ni ethanol (96 fun ogorun). | Pade awọn ibeere |
| Awọn idanimọ | Iwọn gbigba infurarẹẹdi jẹ ibamu pẹlu eyiti o gba pẹlu gliclazide CRS. | Pade awọn ibeere |
| Aimọkan B (Nipasẹ HPLC) | ≤2ppm | 0.5ppm |
| Awọn irin ti o wuwo | ≤10ppm | <10ppm |
| Awọn nkan ti o jọmọ (Nipasẹ HPLC) | Aimọ F ≤0.1% | Ti kii ṣe awari |
| Ọkọọkan aimọ ti ko ni pato ≤0.10% | 0.04% | |
| Apapọ awọn aimọ yatọ si F ≤0.2% | 0.11% | |
| Pipadanu lori gbigbe | ≤0.25% | 0.11% |
| eeru sulfated | ≤0.1% | 0.03% |
| Awọn olomi ti o ku (Nipasẹ GC) | Ethyl acetate NMT 2500 ppm | 265ppm |
| N, N-Dimethylformamide NMT 880 ppm | Ti kii ṣe awari | |
| Ayẹwo | 99.0-101.0%, lori ipilẹ ti o gbẹ. | 100.0% |
| Ipari | Awọn abajade idanwo ni ibamu pẹlu EP8. | |
