Acid Tranexamic (1197-18-8)
ọja Apejuwe
● Tranexamic Acid (1197-18-8)
● CAS No.:·1197-18-8
● EINECS No.: 356.2222
● MF: C8H15NO2
● Package: 25Kg/Drum
● Tranexamic acid (TXA) jẹ oogun ti a lo lati ṣe itọju tabi ṣe idiwọ pipadanu ẹjẹ ti o pọ julọ lati ipalara nla, eje lẹhin ibimọ, iṣẹ abẹ, yiyọ ehin, ẹjẹ imu, ati nkan oṣu ti o wuwo.[2][3]O tun lo fun angioedema ajogunba.[2][4]O jẹ yala ẹnu tabi nipasẹ abẹrẹ sinu iṣọn.
Mechanism ti igbese
Tranexamic acid jẹ afọwọṣe sintetiki ti amino acid lysine.O ṣe iranṣẹ bi antifibrinolytic nipa isọdọtun di mẹrin si marun awọn aaye gbigba lysine lori plasminogen.Eyi dinku iyipada ti plasminogen si plasmin, idilọwọ ibajẹ fibrin ati titọju ilana ilana matrix fibrin.Tranexamic acid ni ni aijọju igba mẹjọ iṣẹ antifibrinolytic ti analogue agbalagba kan, ε-aminocaproic acid. iṣẹ ṣiṣe ti plasmin pẹlu agbara alailagbara (IC50 = 87 mM), ati pe o le dènà aaye ti nṣiṣe lọwọ ti urokinase plasminogen activator (uPA) pẹlu iyasọtọ giga (Ki = 2 mM), ọkan ninu awọn ga julọ laarin gbogbo awọn proteases serine.
Tranexamic acid awọn iṣẹ
Tranexamic acid ni a maa n lo nigbagbogbo lẹhin ibalokanjẹ nla.[13]Tranexamic acid ni a lo lati ṣe idiwọ ati tọju ipadanu ẹjẹ ni ọpọlọpọ awọn ipo, gẹgẹbi awọn ilana ehín, eje nkan oṣu ti o wuwo, ati awọn iṣẹ abẹ pẹlu eewu nla ti isonu ẹjẹ.
| Awọn nkan ti Idanwo | Pharmacopeial àwárí mu | Abajade Idanwo | |
| ÀWỌN ÀWỌN ÀWỌN ADÁJỌ́ | Irisi: Funfun tabi fere funfun, lulú okuta | Funfun okuta lulú | |
| Solubility: Tiotuka larọwọto ninu omi ati ni glacial acetic acid, ni iṣe insoluble ni acetone ati ni ethanol (96%) | Kọja | ||
| Ìdámọ̀ | Spectrophotometry Absorption Infurarẹẹdi: IR spectrum wa ni ibamu pẹlu Tranexamic acid CRS | Kọja | |
| Idanwo | pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Awọn nkan ti o jọmọ (HPLC2.2.29) | Aimọ A≤ 0.1% | Ko ṣe awari | |
| Aimọ́ B≤ 0.2% | 0.03% | ||
| Awọn ohun aimọC Awọn aimọ ti ko ni pato≤ 0.10% Awọn aimọ D Awọn Egbin miiran | 0.002% 0.001% Ko ṣe awari | ||
| Apapọ awọn aimọ ti ko ni pato≤ 0.2% | 0.003% | ||
| Halides Ti ṣalaye bi awọn chlorides | ≤140ppm | <140ppm | |
| Isonu lori Gbigbe | ≤0.5% | 0.026% | |
| Sulfated Ash | ≤0.1% | 0.027% | |
| ASAY | Yẹ ki o wa laarin (orisun ti o gbẹ) 99.0% 〜101.0% | 100.1% | |
